Knoxville is the number one city with the worst COVID-19 infection rate per capita in the United States. According to the latest White House COVID-19 Knoxville is number one in the country for cities with populations between 250,000 and 1 million. Chattanooga was listed as number five. For cities with a population of over 1 million, Nashville was listed as the third worst, behind Riverside, Ca. and Los Angeles, Ca. For cities with a population between 50,000 and 250,000, Johnson City came in at second place and Sevierville at third.